Clinical History
The patient is a 59-year-old woman with progressive weakness x 3 years. Past medical history includes COPD improved with steroids, 30 pack-year history of smoking, coronary artery disease, hypertension & hyperlipidemia. Physical exam shows lower extremity muscle atrophy and 3/5 strength.
What is your diagnosis?
Granulomatous myopathy
Granulomatous myopathy is a rare (2% of inflammatory myopathies) condition. It’s etiologies include sarcoidosis, other autoimmune disease, PD-1 inhibitor associated myopathy, chronic graft-vs-host disease, and natural killer/T-cell lymphoma.
As in the example above, it may coexist with inclusion body myositis (IBM).
Reference: Chompoopong P, Liewluck T. Granulomatous myopathy: Sarcoidosis and beyond. Muscle Nerve. 2023;67(3):193-203.
Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.
