This biopsy shows a chronic active interstitial nephritis with numerous interstitial foamy macrophages containing abundant PAS-positive cytoplasmic granules (Fig 1-3). The findings are consistent with megalocytic interstitial nephritis. Megalocytic interstitial nephritis is an entity closely related to malakoplakia, with the absence of the characteristic Michaelis-Gutmann bodies. This entity most frequently results from a chronic, ascending, bacterial urinary tract infection, most frequently due to E. coli or other gram-negative bacteria.
Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.
Share this article:
Related Posts
