Contraction band artifact (Hematoxylin and Eosin stained section from formalin fixed paraffin embedded tissue 400x magnification)
This skeletal muscle biopsy shows contraction band artifact. This artifact is caused by prolonged ischemic time prior to fixation. To avoid this artifact, the best practice is to triage and submit the skeletal muscle tissue into it’s appropriate “fixative” as soon as possible (i.e. snap freeze, formalin, or glutaraldehyde).
Contraction band artifact (electron microscopy 500x magnification)
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