Education

Arkana offers research and educational opportunities with one thought in mind: the more we all learn, the more we can do.

Educational Opportunities

Arkana offers research and educational opportunities with one thought in mind: the more we can all learn, the more we can do.

Renal Pathology Fellowship

The Arkana renal pathology fellowship is a one-year program designed to train a well-rounded academic renal pathologist.

Mid-Career Transition to Renal Pathologist

Arkana has streamlined a pathway for mid-career pathologists to transition into the field of renal pathology. See if this career change is right for you.

Immersive Rotation in Renal Pathology

We are offering residents the opportunity for an immersive rotation in renal pathology through a two-week or one-month visit.

Educational Resources

Renal Pathology Quizzes

Test your diagnostic chops or study for upcoming board exams with our renal pathology quizzes.

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Research Publications

Our curiosity drives our research efforts. Find out what questions we’ve been asking in our recent publications.

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Physician Resources

Everything from teaching images to links to common nephrology organizations, we strive to provide useful resources to nephrologists.

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Renal Pathology Quizzes

EM image taken from renal biopsy at arkana laboratories

Electron Microscopy

Electron microscopy is an important tool in a renal pathologist’s arsenal as in some diseases, it is the only way to make the diagnosis. Test your skills with these images of classic electron microscopic findings in renal biopsies.

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positive Immunofluorescence stain of renal biopsy

Immunofluorescence

Immunofluorescence plays a major role in the evaluation of a medical renal biopsy. Try your hand at this next set of immunofluorescence images on classic diseases that we see daily and encompass all compartments of the kidney (i.e. glomeruli, tubulointerstitium, vessels).

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large glomerulus on PAS stain

Tubulointerstitial Diseases

Although glomerular diseases usually take the limelight when it comes to renal pathology, the tubulointerstitial compartment is no less important. In this section, a few of the most characteristic tubulointerstitial disease entities will be featured and highlighted.

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CMV nuclear inclusion in CMV nephritis from transplant biopsy sent to Arkana Laboratories

Glomerular Diseases Pt 1

In this quiz, you will be introduced to the main patterns of glomerular injury and some of the main disease entities that are seen in association with those patterns.

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Our Research

Over the last few years, our curiosity, innovations, and growing team of doctors—the finest and most concentrated in the field anywhere in the world—have all contributed to a constantly expanding practice.

 

 

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Shiga toxin targets the podocyte causing hemolytic uremic syndrome through… Shiga toxin targets the podocyte causing hemolytic…

By Bowen EE, Hurcombe JA, Barrington F, Keir LS, Farmer LK, Wherlock MD, Ortiz-Sandoval CG, Bruno V, Bohorquez-Hernandez A, Diatlov D, Rostam-Shirazi N, Wells S, Stewart M,…

October 2023

  • The podocyte is likely the reason Shiga toxin targets the…

    • The podocyte is likely the reason Shiga toxin targets the glomerulus in STEC-HU
    • Podocyte-to-glomerular endothelial cell…

Read on cell.com

Nephronophthisis: a pathological and genetic perspective Nephronophthisis: a pathological and genetic…

By Wolf MTF, Bonsib SM, Larsen CP, Hildebrandt F

November 2023

Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease and is one of the most frequent genetic causes…

Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease and is one of the most frequent genetic causes for kidney failure (KF) in children and adolescents. Over 20 genes cause NPHP and over 90 genes contribute to renal ciliopathies…

Read on Springer Link

Development and Validation of a Multiclass Model Defining Molecular Archetypes of… Development and Validation of a Multiclass Model…

By Hao Zhang, Randy S. Haun, Francois Collin, Clarissa Cassol, Johnathan O.H. Napier, Jon Wilson, Samar Hassen, Kerime Ararat, Christie Boils, Nidia Messias, Tiffany N.…

December 2023

Gene expression profiling from formalin-fixed paraffin-embedded (FFPE) renal allograft biopsies is a promising approach…

Gene expression profiling from formalin-fixed paraffin-embedded (FFPE) renal allograft biopsies is a promising approach for feasibly providing a molecular diagnosis of rejection. However, large-scale studies evaluating the performance of models…

Read on Laboratory Investigation

Acute Kidney Injury In Severe COVID-19 Has Similarities to Sepsis-Associated… Acute Kidney Injury In Severe COVID-19 Has…

By Alexander MP, Mangalaparthi KK, Madugundu AK, Moyer AM, Adam BA, Mengel M, Singh S, Herrmann SM, Rule AD, Cheek EH, Herrera Hernandez LP, Graham RP, Aleksandar D, Aubry…

October 2021

Objective: To compare coronavirus disease 2019 (COVID-19) acute kidney injury (AKI)…

Objective: To compare coronavirus disease 2019 (COVID-19) acute kidney injury (AKI) to sepsis-AKI (S-AKI). The morphology and transcriptomic and proteomic characteristics of autopsy kidneys were analyzed.

Acute tubular injury and immune cell infiltration in coronavirus disease 2019 kidneys
Read on PubMed

Apol1-Associated Collapsing Focal Segmental Glomerulosclerosis In A Patient With… Apol1-Associated Collapsing Focal Segmental…

By Abid Q, Best Rocha A, Larsen CP, Schulert G, Marsh R, Yasin S, Patty-Resk C, Valentini RP, Adams M, Baracco R

February 2020

Apolipoprotein L1 (APOL1) risk variants G1 and G2 are known to result in risk for kidney disease in patients of African…

Apolipoprotein L1 (APOL1) risk variants G1 and G2 are known to result in risk for kidney disease in patients of African ancestry.

Collapsing glomerulopathy. (A, B) Collapse of the glomerular tuft associated with prominent epithelial cell hyperplasia and hypertrophy
Read on PubMed

Educational Blog Series

Russell Bodies on Gomori Trichrome Stain
Neuro Notes

Polymyositis With Plasma Cells

This 50-year-old patients muscle biopsy showed morphologic changes of polymyositis. Their past medical history is significant for rheumatoid arthritis. What…

Jon Wilson, MD neuropathologist at arkana laboratories
By Jon Wilson, MD
Systemic Lupus Erythematosus, SLE, lupus nephritis, arkana laboratories, disease week, renal pathology
Disease Week

NIH Lupus Nephritis Activity and Chronicity Indices

NIH Lupus Nephritis Activity and Chronicity Indices: A way to monitor response to treatment and disease progression. A semi-quantitative grading…

Tiffany Caza, MD, PhD renal pathologist at arkana laboratories
By Tiffany Caza, MD
Eosinophil-Rich Inflammation in Diabetic Glomerulopathy
Teaching Points

Eosinophil-Rich Inflammation in Diabetic Glomerulopathy

These photomicrographs are from a patient with diabetic nephropathy as evidenced by the Kimmelstiel-Wilson nodules in the glomerulus present on…

Chris Larsen, MD renal pathologist at arkana laboratories
By Chris Larsen, MD
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renal biopsy stained positive for Alport's Syndrome