Research Publications

Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

By Johnathan O.H. Napier, Lyle J. Burdine, Coley SM, Sharma SG, Cassol CA, Kenan DJ, Eigbire-Molen O

July 2024

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue,…

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue, based on the amount of cortex. The model was developed on smartphone images of 747 kidney biopsy cores from deceased donor kidneys,…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

By Palmer MB, Royal V, Jennette JC, Smith AR, Liu Q, Ambruzs JM, Andeen NK, D'Agati VD, Fogo AB, Gaut J, Gbadegesin RA, Greenbaum LA, Hou J, Helmuth ME, Lafayette RA,…

October 2023

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD),…

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA nephropathy. We developed a conventional,…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

By Kouri AM, Caza TN, Beck LH Jr., Misurac JM, Evans MD, Phillips CL, Eadon MT, Larsen CP, Andreoli SP, Bu L, Rheault MN, Khalid M

August 2023

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected…

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected children are scarce. In recent years, several novel antigens have been implicated in the pathogenesis of PMN. However, the…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

By Bu L, Said SM, Herrera Hernandez L, Taheri Z, Spry L, Rosenthal BS, Das A, Madden B, Larsen CP, Kim Y, Sethi S, Nasr SH

August 2023

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously…

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously addressed only in case reports or small series (≤12 patients). The target antigen(s) in MN associated with anti-GBM nephritis are…

About Our Research

We’ve doubled down on our commitment to research and teaching.

Arkana is a learning, teaching, and innovating practice with one unifying passion – to actively work toward the day that our research yields breakthroughs that make our services unnecessary. Eradicating rare and common diseases is the end game of all of our efforts because patient health is foremost in our minds every day. Read about some of our latest publications below.

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(475 Results)

Clinicopathologic Features of Kidney Disease in Patients With Cystic Fibrosis

By Caza TN, Walker PD

Extrapulmonary complications of cystic fibrosis (CF) occur in nearly all adults living with the disease and renal manifestations are no…

Read on NCBI

• July 2024
Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical Kidney Biopsy

By Johnathan O.H. Napier, Lyle J. Burdine, Coley SM, Sharma SG, Cassol CA, Kenan DJ, Eigbire-Molen O

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue, based on the…

Read on Science Direct

• July 2024
Clinicopathologic Features of Antibrush Border Antibody Disease

By Nidia Messias, Randolph Hennigar, Nicole K. Andeen, Christine VanBeek, Matthew Palmer, Lakshna Sankar, Pooja Sanghi, Kumar Dinesh, Lance Dicker, Anatoly Urisman, Murphy JD, Caza TN, Cassol CA, Storey A, Ambruzs JM, Boils CL, Walker PD, Sharma SG, Larsen CP

Antibrush Border Antibody Disease (ABBA), is a rare condition affecting the kidneys, particularly in older individuals, leading to kidney failure.…

Read on kirereports.org

• February 2024
Development and Validation of a Multiclass Model Defining Molecular Archetypes of Kidney Transplant Rejection: A Large Cohort Study of the Banff Human Organ Transplant Gene Expression Panel

By Hao Zhang, Francois Collin, Johnathan O.H. Napier, Kerime Ararat, Nidia Messias, Nikhil Agrawal, Grigoriy Shekhtman, Wenlan Tian, Titte Srinivas, Kunbin Qu, Robert N. Woodward, Steven Stone, Haun RS, Cassol CA, Wilson JD, Hassen SI, Boils CL, Caza TN, Cossey LN, Sharma SG, Ambruzs JM, Larsen CP, Coley SM

Gene expression profiling from formalin-fixed paraffin-embedded (FFPE) renal allograft biopsies is a promising approach for feasibly providing a molecular diagnosis…

Read on Laboratory Investigation

• December 2023
Nephronophthisis: a pathological and genetic perspective

By Wolf MTF, Bonsib SM, Larsen CP, Hildebrandt F

Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease and is one of the most frequent genetic causes for kidney…

Read on Springer Link

• November 2023
The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

By Roufosse C, Naesens M, Haas M, Lefaucheur C, Mannon RB, Afrouzian M, Alachkar N, Aubert O, Bagnasco SM, Batal I, Bellamy COC, Broecker V, Budde K, Clahsen-Van Groningen M, Coley SM, Cornell LD, Dadhania D, Demetris AJ, Einecke G, Farris AB, Fogo AB, Friedewald J, Gibson IW, Horsfield C, Huang E, Husain SA, Jackson AM, Kers J, Kikić Ž, Klein A, Kozakowski N, Liapis H, Mangiola M, Montgomery RA, Nankinvell B, Neil DAH, Nickerson P, Rabant M, Randhawa P, Riella LV, Rosales I, Royal V, Sapir-Pichhadze R, Sarder P, Sarwal M, Schinstock C, Stegall M, Solez K, van der Laak J, Wiebe C, Colvin RB, Loupy A, Mengel M

The XVIth Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from September 19 to 23, 2022, as…

Read on amjtransplant.org

• November 2023
Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria, Reproducibility, and Clinicopathologic Correlations

By Palmer MB, Royal V, Jennette JC, Smith AR, Liu Q, Ambruzs JM, Andeen NK, D'Agati VD, Fogo AB, Gaut J, Gbadegesin RA, Greenbaum LA, Hou J, Helmuth ME, Lafayette RA, Liapis H, Robinson B, Stokes MB, Twombley K, Yin H, Nast CC; CureGN Consortium

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous…

Read on Karger.com

• October 2023
Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation

By Bowen EE, Hurcombe JA, Barrington F, Keir LS, Farmer LK, Wherlock MD, Ortiz-Sandoval CG, Bruno V, Bohorquez-Hernandez A, Diatlov D, Rostam-Shirazi N, Wells S, Stewart M, Teboul L, Lay AC, Butler MJ, Pope RJP, Larkai EMS, Morgan BP, Moppett J, Satchell SC, Welsh GI, Walker PD, Licht C, Saleem MA, Coward RJM

The podocyte is likely the reason Shiga toxin targets the glomerulus in STEC-HU Podocyte-to-glomerular endothelial cell crosstalk occurs in STEC-HU…

Read on cell.com

• October 2023
Corrigendum: Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation

By Afrouzian M, Kozakowski N, Liapis H, Broecker V, Truong L, Avila-Casado C, Regele H, Seshan S, Ambruzs JM, Farris AB, Buob D, Chander PN, Cheraghvandi L, Clahsen-van Groningen MC, de Almeida Araujo S, Baydar DE, Formby M, Ljubanovic DG, Hernandez LH, Honsova E, Mohamed N, Ozluk Y, Rabant M, Royal V, Stevenson HL, Toniolo MF, Taheri D

In the published article, there was an error with affiliations 3 and 4. Instead of 3Department of Pathology and Immunology,…

Read on FrontiersPartnerships.org

• October 2023
Corrigendum: Thrombotic Microangiopathy in the Renal Allograft: Results of the TMA Banff Working Group Consensus on Pathologic Diagnostic Criteria

By Afrouzian M, Kozakowski N, Liapis H, Broecker V, Truong L, Avila-Casado C, Regele H, Seshan S, Ambruzs JM, Farris AB, Buob D, Chander PN, Cheraghvandi L, Clahsen-van Groningen MC, de Almeida Araujo S, Baydar DE, Formby M, Ljubanovic DG, Hernandez LH, Honsova E, Mohamed N, Ozluk Y, Rabant M, Royal V, Stevenson HL, Toniolo MF, Taheri D

In the published article, there was an error with affiliations 3 and 4. Instead of 3Department of Pathology and Immunology,…

Read on FrontiersPartnerships.org

• October 2023

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Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

About Our Research

All Publications

Clinicopathologic Features of Kidney Disease in Patients With Cystic Fibrosis

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical Kidney Biopsy

Clinicopathologic Features of Antibrush Border Antibody Disease

Development and Validation of a Multiclass Model Defining Molecular Archetypes of Kidney Transplant Rejection: A Large Cohort Study of the Banff Human Organ Transplant Gene Expression Panel

Nephronophthisis: a pathological and genetic perspective

The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria, Reproducibility, and Clinicopathologic Correlations

Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation

Corrigendum: Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation

Corrigendum: Thrombotic Microangiopathy in the Renal Allograft: Results of the TMA Banff Working Group Consensus on Pathologic Diagnostic Criteria

Featured Publications

About Our Research

All Publications

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