Research Publications

Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

By Johnathan O.H. Napier, Lyle J. Burdine, Coley SM, Sharma SG, Cassol CA, Kenan DJ, Eigbire-Molen O

July 2024

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue,…

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue, based on the amount of cortex. The model was developed on smartphone images of 747 kidney biopsy cores from deceased donor kidneys,…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

By Palmer MB, Royal V, Jennette JC, Smith AR, Liu Q, Ambruzs JM, Andeen NK, D'Agati VD, Fogo AB, Gaut J, Gbadegesin RA, Greenbaum LA, Hou J, Helmuth ME, Lafayette RA,…

October 2023

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD),…

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA nephropathy. We developed a conventional,…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

By Kouri AM, Caza TN, Beck LH Jr., Misurac JM, Evans MD, Phillips CL, Eadon MT, Larsen CP, Andreoli SP, Bu L, Rheault MN, Khalid M

August 2023

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected…

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected children are scarce. In recent years, several novel antigens have been implicated in the pathogenesis of PMN. However, the…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

By Bu L, Said SM, Herrera Hernandez L, Taheri Z, Spry L, Rosenthal BS, Das A, Madden B, Larsen CP, Kim Y, Sethi S, Nasr SH

August 2023

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously…

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously addressed only in case reports or small series (≤12 patients). The target antigen(s) in MN associated with anti-GBM nephritis are…

About Our Research

We’ve doubled down on our commitment to research and teaching.

Arkana is a learning, teaching, and innovating practice with one unifying passion – to actively work toward the day that our research yields breakthroughs that make our services unnecessary. Eradicating rare and common diseases is the end game of all of our efforts because patient health is foremost in our minds every day. Read about some of our latest publications below.

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(475 Results)

Nell1 Is A Target Antigen In Malignancy-Associated Membranous Nephropathy

By Caza TN, Hassen SI, Dvanajscak Z, Kuperman M, Edmondson R, Herzog C, Storey A, Arthur J, Cossey LN, Sharma SG, Kenan DJ, Larsen CP

Patients with membranous nephropathy have an increased risk of malignancy compared to the general population, but the target antigen for…

Read on PubMed

• April 2021
Assessment Of A Computerized Quantitative Quality Control Tool For Whole Slide Images Of Kidney Biopsies

By Zee J, Cassol C, Palmer M, Chen Y, Barisoni L, Smith A, Jayapandian C, Hodgin J, Howell D, Thomas D, Farris AB 3rd, Perkinson K, Madabhushi A, Janowczyk A

Inconsistencies in the preparation of histology slides and whole-slide images (WSIs) may lead to challenges with subsequent image analysis and…

Read on PubMed

• March 2021
Immunoglobulin-Negative DNAJB9-Associated Fibrillary Glomerulonephritis: A Report of 9 Cases

By Said SM, Rocha AB, Royal V, Valeri AM, Larsen CP, Theis JD, Vrana JA, McPhail ED, Bandi L, Safabakhsh S, Barnes C, Cornell LD, Fidler ME, Alexander MP, Leung N, Nasr SH

Fibrillary glomerulonephritis (FGN) was previously defined by glomerular deposition of haphazardly oriented fibrils that stain with antisera to immunoglobulins but…

Read on PubMed

• March 2021
Kidney Biopsy Findings In Patients With COVID-19, Kidney Injury, And Proteinuria

By Nasr SH, Alexander MP, Cornell LD, Herrera LH, Fidler ME, Said SM, Zhang P, Larsen CP, Sethi S

Acute tubular injury (AKI) develops in up to 37% of hospitalized patients with COVID-19 and its pathophysiology has not been…

Read on PubMed

• March 2021
Masson Trichrome And Sulfated Alcian Blue Stains Distinguish Light Chain Deposition Disease From Amyloidosis In The Lung

By Kunnath-Velayudhan S, Larsen BT, Coley SM, De Michele S, Santoriello D, Colby TV, Bhagat G, Saqi A

Light chain deposition disease, characterized by nonamyloidogenic deposits of immunoglobulin light chains, is rare in the lung and possibly underdiagnosed…

Read on PubMed

• March 2021
Membranous Nephropathy In A Patient With Coronavirus Disease 2019 (Covid-19): A Case Report

By Miao J, Fidler ME, Nasr SH, Larsen CP, Zoghby ZM

Though respiratory, immune, and coagulation systems are major targets of coronavirus disease 2019 (COVID-19), kidney dysfunction, presenting with acute kidney…

Read on PubMed

• February 2021
An Efficient Synthetic Route To L-γ-Methyleneglutamine And Its Amide Derivatives, And Their Selective Anticancer Activity

By Hossain MI, Thomas AG, Mahdi F, Adam AT, Akins NS, Woodard MM, Paris JJ, Slusher BS, Le HV

In cancer cells, glutaminolysis is the primary source of biosynthetic precursors, fueling the TCA cycle with glutamine-derived -ketoglutarate. The enhanced…

Read on PubMed

• February 2021
Spontaneous Remission Of Genetic, Apparent Primary, Fsgs Presenting With Nephrotic Syndrome Challenges Traditional Notions Of Primary Fsgs

By Oo SZMWH, Freese ME, Holanda DG, Thomas CP

Read on PubMed

• February 2021
Development And Evaluation Of Deep Learning-Based Segmentation Of Histologic Structures In The Kidney Cortex With Multiple Histologic Stains

By Jayapandian CP, Chen Y, Janowczyk AR, Palmer MB, Cassol CA, Sekulic M, Hodgin JB, Zee J, Hewitt SM, O'Toole J, Toro P, Sedor JR, Barisoni L, Madabhushi A; Nephrotic Syndrome Study Network (NEPTUNE)

The application of deep learning for automated segmentation (delineation of boundaries) of histologic primitives (structures) from whole slide images can…

Read on PubMed

• January 2021
Recurrence of Atrial Myxoma in Pregnancy: Successful Intrapartum Management and Postpartum Resection

By Joudi N, Levin E, Miller PP, Nieman K, Lathi R, Boyd J, El-Sayed Y, Bianco K, Khandelwal A

Cardiac myxoma in pregnant women is extremely rare; with only 50 cases reported in the literature. Management warrants close consideration…

Read on Fortune Journals

• January 2021

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Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

About Our Research

All Publications

Nell1 Is A Target Antigen In Malignancy-Associated Membranous Nephropathy

Assessment Of A Computerized Quantitative Quality Control Tool For Whole Slide Images Of Kidney Biopsies

Immunoglobulin-Negative DNAJB9-Associated Fibrillary Glomerulonephritis: A Report of 9 Cases

Kidney Biopsy Findings In Patients With COVID-19, Kidney Injury, And Proteinuria

Masson Trichrome And Sulfated Alcian Blue Stains Distinguish Light Chain Deposition Disease From Amyloidosis In The Lung

Membranous Nephropathy In A Patient With Coronavirus Disease 2019 (Covid-19): A Case Report

An Efficient Synthetic Route To L-γ-Methyleneglutamine And Its Amide Derivatives, And Their Selective Anticancer Activity

Spontaneous Remission Of Genetic, Apparent Primary, Fsgs Presenting With Nephrotic Syndrome Challenges Traditional Notions Of Primary Fsgs

Development And Evaluation Of Deep Learning-Based Segmentation Of Histologic Structures In The Kidney Cortex With Multiple Histologic Stains

Recurrence of Atrial Myxoma in Pregnancy: Successful Intrapartum Management and Postpartum Resection

Featured Publications

About Our Research

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