Research Publications

Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

By Johnathan O.H. Napier, Lyle J. Burdine, Coley SM, Sharma SG, Cassol CA, Kenan DJ, Eigbire-Molen O

July 2024

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue,…

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue, based on the amount of cortex. The model was developed on smartphone images of 747 kidney biopsy cores from deceased donor kidneys,…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

By Palmer MB, Royal V, Jennette JC, Smith AR, Liu Q, Ambruzs JM, Andeen NK, D'Agati VD, Fogo AB, Gaut J, Gbadegesin RA, Greenbaum LA, Hou J, Helmuth ME, Lafayette RA,…

October 2023

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD),…

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA nephropathy. We developed a conventional,…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

By Kouri AM, Caza TN, Beck LH Jr., Misurac JM, Evans MD, Phillips CL, Eadon MT, Larsen CP, Andreoli SP, Bu L, Rheault MN, Khalid M

August 2023

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected…

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected children are scarce. In recent years, several novel antigens have been implicated in the pathogenesis of PMN. However, the…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

By Bu L, Said SM, Herrera Hernandez L, Taheri Z, Spry L, Rosenthal BS, Das A, Madden B, Larsen CP, Kim Y, Sethi S, Nasr SH

August 2023

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously…

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously addressed only in case reports or small series (≤12 patients). The target antigen(s) in MN associated with anti-GBM nephritis are…

About Our Research

We’ve doubled down on our commitment to research and teaching.

Arkana is a learning, teaching, and innovating practice with one unifying passion – to actively work toward the day that our research yields breakthroughs that make our services unnecessary. Eradicating rare and common diseases is the end game of all of our efforts because patient health is foremost in our minds every day. Read about some of our latest publications below.

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International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic)

By Soda T, McLoughlin DM, Clark SR, Oltedal L, Kessler U, Haavik J, Bousman C, Smith DJ, Bioque M, Clements CC, Loo C, Vila-Rodriguez F, Minelli A, Mickey BJ, Milev R, Docherty AR, Langan Martin J, Achtyes ED, Arolt V, Redlich R, Dannlowski U, Cardoner N, Clare E, Craddock N, Di Florio A, Dmitrzak-Weglarz M, Forty L, Gordon-Smith K, Husain M, Ingram WM, Jones L, Jones I, Juruena M, Kirov G, Landén M, Müller DJ, Nordensköld A, Pålsson E, Paul M, Permoda A, Pliszka B, Rea J, Schubert KO, Sonnen JA, Soria V, Stageman W, Takamiya A, Urretavizacaya M, Watson S, Zavorotny M, Young AH, Vieta E, Rybakowski JK, Gennarelli M, Zandi PP, Sullivan PF, Baune BT

Recent genome-wide association studies have demonstrated that the genetic burden associated with depression correlates with depression severity. Therefore, conducting genetic…

Read on PubMed

• October 2020
Resistant Starch Slows The Progression Of Ckd In The 5/6 Nephrectomy Mouse Model

By Karaduta O, Glazko G, Dvanajscak Z, Arthur J, Mackintosh S, Orr L, Rahmatallah Y, Yeruva L, Tackett A, Zybailov B

Resistant Starch (RS) improves CKD outcomes. In this report, we study how RS modulates host-microbiome interactions in CKD by measuring…

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• October 2020
Covan Is The New Hivan: The Re-Emergence Of Collapsing Glomerulopathy With Covid-19

By Velez JCQ, Caza T, Larsen CP

Reports of collapsing glomerulopathy in patients of African ancestry and high-riskAPOL1genotype infected with SARS-CoV-2 have emerged during the COVID-19 pandemic.

Read on PubMed

• October 2020
Renal Hypoplasia, From Grossly Insufficient To Not Quite Enough: Consideration For Expanded Concepts Based Upon The Author’s Perspective With Historical Review

By Bonsib SM

Hypoplasia is defined in the Merriman-Webster dictionary as “a condition of arrested development in which an organ, or part, remains…

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• September 2020
Histopathologic And Ultrastructural Findings In Postmortem Kidney Biopsy Material In 12 Patients With Aki And Covid-19

By Golmai P, Larsen CP, DeVita MV, Wahl SJ, Weins A, Rennke HG, Bijol V, Rosenstock JL

Since its emergence in Wuhan, China, coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world.

Read on PubMed

• September 2020
COVID-19-Associated Kidney Injury: A Case Series Of Kidney Biopsy Findings

By Sharma P, Uppal NN, Wanchoo R, Shah HH, Yang Y, Parikh R, Khanin Y, Madireddy V, Larsen CP, Jhaveri KD, Bijol V, Northwell Nephrology COVID-19 Research Consortium

Reports show that AKI is a common complication of severe coronavirus disease 2019 (COVID-19) in hospitalized patients

Read on PubMed

• September 2020
Large And Uneven Bites In End-To-End Anastomosis Of The Rat Femoral Artery

By Zheng YD, Nicolas CF, Corvi JJ, Kurtzman JS, Park KH, Coley SM, Marboe CC, Akelina Y, Strauch RJ

Successful microvascular anastomosis depends on sutures that adequately oppose both cut vessel edges.

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• September 2020
HIV-1 Tat Promotes Age-Related Cognitive, Anxiety-Like, And Antinociceptive Impairments In Female Mice That Are Moderated By Aging And Endocrine Status

By Qrareya AN, Mahdi F, Kaufman M, Ashpole NM, Paris JJ

Hypogonadism is a common comorbidity associated with HIV-1 that is more prevalent among infected individuals over the age of 45.…

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• September 2020
Impact Of Deceased Donor Kidney Procurement Biopsy Technique On Histologic Accuracy

By Husain SA, Shah V, Alvarado Verduzco H, King KL, Brennan C, Batal I, Coley SM, Hall IE, Stokes MB, Dube GK, Crew RJ, Perotte A, Natarajan K, Carpenter D, Sandoval PR, Santoriello D, D'Agati V, Cohen DJ, Ratner L, Markowitz G, Mohan S

The factors that influence deceased donor kidney procurement biopsy reliability are not well established. We examined the impact of biopsy…

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• August 2020
AKI And Collapsing Glomerulopathy Associated With COVID-19 And APOL 1 High-Risk Genotype

By Wu H, Larsen CP, Hernandez-Arroyo CF, Mohamed MMB, Caza T, Sharshir M, Chughtai A, Xie L, Gimenez JM, Sandow TA, Lusco MA, Yang H, Acheampong E, Rosales IA, Colvin RB, Fogo AB, Velez JCQ

Kidney involvement is a feature of COVID-19 and it can be severe in Black patients. Previous research linked increased susceptibility…

Read on PubMed

• August 2020

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Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

About Our Research

All Publications

International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic)

Resistant Starch Slows The Progression Of Ckd In The 5/6 Nephrectomy Mouse Model

Covan Is The New Hivan: The Re-Emergence Of Collapsing Glomerulopathy With Covid-19

Renal Hypoplasia, From Grossly Insufficient To Not Quite Enough: Consideration For Expanded Concepts Based Upon The Author’s Perspective With Historical Review

Histopathologic And Ultrastructural Findings In Postmortem Kidney Biopsy Material In 12 Patients With Aki And Covid-19

COVID-19-Associated Kidney Injury: A Case Series Of Kidney Biopsy Findings

Large And Uneven Bites In End-To-End Anastomosis Of The Rat Femoral Artery

HIV-1 Tat Promotes Age-Related Cognitive, Anxiety-Like, And Antinociceptive Impairments In Female Mice That Are Moderated By Aging And Endocrine Status

Impact Of Deceased Donor Kidney Procurement Biopsy Technique On Histologic Accuracy

AKI And Collapsing Glomerulopathy Associated With COVID-19 And APOL 1 High-Risk Genotype

Featured Publications

About Our Research

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