Research Publications

Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

By Johnathan O.H. Napier, Lyle J. Burdine, Coley SM, Sharma SG, Cassol CA, Kenan DJ, Eigbire-Molen O

July 2024

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue,…

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue, based on the amount of cortex. The model was developed on smartphone images of 747 kidney biopsy cores from deceased donor kidneys,…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

By Palmer MB, Royal V, Jennette JC, Smith AR, Liu Q, Ambruzs JM, Andeen NK, D'Agati VD, Fogo AB, Gaut J, Gbadegesin RA, Greenbaum LA, Hou J, Helmuth ME, Lafayette RA,…

October 2023

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD),…

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA nephropathy. We developed a conventional,…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

By Kouri AM, Caza TN, Beck LH Jr., Misurac JM, Evans MD, Phillips CL, Eadon MT, Larsen CP, Andreoli SP, Bu L, Rheault MN, Khalid M

August 2023

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected…

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected children are scarce. In recent years, several novel antigens have been implicated in the pathogenesis of PMN. However, the…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

By Bu L, Said SM, Herrera Hernandez L, Taheri Z, Spry L, Rosenthal BS, Das A, Madden B, Larsen CP, Kim Y, Sethi S, Nasr SH

August 2023

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously…

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously addressed only in case reports or small series (≤12 patients). The target antigen(s) in MN associated with anti-GBM nephritis are…

About Our Research

We’ve doubled down on our commitment to research and teaching.

Arkana is a learning, teaching, and innovating practice with one unifying passion – to actively work toward the day that our research yields breakthroughs that make our services unnecessary. Eradicating rare and common diseases is the end game of all of our efforts because patient health is foremost in our minds every day. Read about some of our latest publications below.

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Light Chain Only Variant Of Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits Is Associated With A High Detection Rate Of The Pathogenic Plasma Cell Clone

By Nasr SH, Larsen CP, Sirac C, Theis JD, Domenger C, Chauvet S, Javaugue V, Hogan JJ, Said SM, Dasari S, Vrana JA, McPhail ED, Cornell LD, Vilaine E, Massy ZA, Boffa JJ, Buob D, Toussaint S, Guincestre T, Touchard G, D'Agati VD, Leung N, Bridoux F

IgG (mainly IgG3) is the most commonly involved isotype in proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Here we describe…

Read on PubMed

• March 2020
Central Actions Of 3α,5α-THP Involving NMDA And GABAA Receptors Regulate Affective And Sexual Behavior Of Female Rats

By Frye CA, Qrareya AN, Llaneza DC, Paris JJ

The neurosteroid, 5-pregnan-3-ol-20-one (known as “allopregnanolone” or 3,5-THP), is produced in the midbrain ventral tegmental area (VTA), independent of peripheral…

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• February 2020
Apol1-Associated Collapsing Focal Segmental Glomerulosclerosis In A Patient With Stimulator Of Interferon Genes (Sting)-Associated Vasculopathy With Onset In Infancy (Savi)

By Abid Q, Best Rocha A, Larsen CP, Schulert G, Marsh R, Yasin S, Patty-Resk C, Valentini RP, Adams M, Baracco R

Apolipoprotein L1 (APOL1) risk variants G1 and G2 are known to result in risk for kidney disease in patients of…

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• February 2020
Resolution Of Syphilis-Related Rapidly Progressive Glomerulonephritis With Penicillin Therapy: Case Report

By Nandikanti DK, George LK, Walker PD, Kumar A, Wall BM

Renal manifestations of syphilis are variable, with membranous nephropathy being the most commonly described lesion.

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• February 2020
Membranous Nephropathy With Crescents

By Alawieh R, Brodsky SV, Satoskar AA, Nadasdy T, Parikh SV, Rovin B, Cassol CA

Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults and can be primary or secondary. Primary MN…

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• January 2020
Pregnane Steroidogenesis Is Altered By HIV-1 Tat And Morphine: Physiological Allopregnanolone Is Protective Against Neurotoxic And Psychomotor Effects

By Paris JJ, Liere P, Kim S, Mahdi F, Buchanan M, Nass SR, Qrareya AN, Salahuddin MF, Pianos A, Fernandez N, Shariat-Madar Z, Knapp PE, Schumacher M, Hauser KF

Pregnane steroids, particularly allopregnanolone (AlloP), are neuroprotective in response to central insult. While unexploredin vivo, AlloP may confer protection against…

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• January 2020
Hemolysis-Associated Hemoglobin Cast Nephropathy Results From A Range Of Clinicopathologic Disorders

By Dvanajscak Z, Walker PD, Cossey LN, Messias NC, Boils CL, Kuperman MB, Larsen CP

Intravascular hemolysis is relatively rare but can lead to acute kidney injury (AKI), from increased destruction of erythrocytes and release…

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• December 2019
Association Between Sepsis And Microvascular Brain Injury

By Ehlenbach WJ, Sonnen JA, Montine TJ, Larson EB

Many survivors of sepsis suffer long-term cognitive impairment, but the mechanisms of this association remain unknown. The objective of this…

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• November 2019
Syndecan-1 facilitates breast cancer metastasis to the brain

By Sayyad MR, Puchalapalli M, Vergara NG, Wangensteen SM, Moore M, Mu L, Edwards C, Anderson A, Kall S, Sullivan M, Dozmorov M, Singh JA, Idowu MO, Koblinski JE

Although survival rates for patients with localized breast cancer have increased, patients with metastatic breast cancer still have poor prognosis.…

Read on PubMed

• November 2019
Persistent organic pollutants (POPs) increase rage signaling to promote downstream cardiovascular remodeling

By Coole JB, Burr SS, Kay AM, Singh JA, Kondakala S, Yang EJ, Kaplan BLF, Howell GE 3rd, Stewart JA Jr

Exposure to environmental contaminants and consumption of a high, saturated fatty diet has been demonstrated to promote precursors for metabolic…

Read on PubMed

• October 2019

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Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

About Our Research

All Publications

Light Chain Only Variant Of Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits Is Associated With A High Detection Rate Of The Pathogenic Plasma Cell Clone

Central Actions Of 3α,5α-THP Involving NMDA And GABAA Receptors Regulate Affective And Sexual Behavior Of Female Rats

Apol1-Associated Collapsing Focal Segmental Glomerulosclerosis In A Patient With Stimulator Of Interferon Genes (Sting)-Associated Vasculopathy With Onset In Infancy (Savi)

Resolution Of Syphilis-Related Rapidly Progressive Glomerulonephritis With Penicillin Therapy: Case Report

Membranous Nephropathy With Crescents

Pregnane Steroidogenesis Is Altered By HIV-1 Tat And Morphine: Physiological Allopregnanolone Is Protective Against Neurotoxic And Psychomotor Effects

Hemolysis-Associated Hemoglobin Cast Nephropathy Results From A Range Of Clinicopathologic Disorders

Association Between Sepsis And Microvascular Brain Injury

Syndecan-1 facilitates breast cancer metastasis to the brain

Persistent organic pollutants (POPs) increase rage signaling to promote downstream cardiovascular remodeling

Featured Publications

About Our Research

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