Featured Publications
About Our Research
We’ve doubled down on our commitment to research and teaching.
Arkana is a learning, teaching, and innovating practice with one unifying passion – to actively work toward the day that our research yields breakthroughs that make our services unnecessary. Eradicating rare and common diseases is the end game of all of our efforts because patient health is foremost in our minds every day. Read about some of our latest publications below.
All Publications
(475 Results)
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ABCC9 Gene Polymorphism Is Associated With Hippocampal Sclerosis Of Aging Pathology
Hippocampal sclerosis of aging (HS-Aging) is a high-morbidity brain disease in the elderly but risk factors are largely unknown.
Read on PubMed• April 2017
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Conditional Human Immunodeficiency Virus Transactivator Of Transcription Protein Expression Induces Depression-Like Effects And Oxidative Stress
The prevalence of major depression in those with HIV/AIDS is substantially higher than in the general population. Mechanisms underlying this…
Read on PubMed• April 2017
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BK Polyomavirus Genomic Integration And Large T Antigen Expression: Evolving Paradigms In Human Oncogenesis
Human polyomaviruses are ubiquitous, with primary infections that typically occur during childhood and subsequent latency that may last a lifetime.
Read on PubMed• February 2017
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A Rare Case Of Renal Thrombotic Microangiopathy Associated With Castleman’s Disease
Castleman’s disease (CD) is an uncommon, heterogeneous lympho-proliferative disorder leading to high circulating levels of interleukin-6 (IL-6) and vascular endothelial…
Read on PubMed• February 2017
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HIV-1 Tat Disrupts Blood-Brain Barrier Integrity And Increases Phagocytic Perivascular Macrophages And Microglia In The Dorsal Striatum Of Transgenic Mice
HIV-1 infection results in blood-brain barrier (BBB) disruption, which acts as a rate-limiting step for HIV-1 entry into the CNS…
Read on PubMed• January 2017
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Association Between Cholesterol Exposure And Neuropathological Findings: The ACT Study
We characterized the relationship between late life cholesterol exposure and neuropathological outcomes in a community-based, older adult cohort.
Read on PubMed• January 2017
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Use Of Analgesics (Opioids And Nonsteroidal Anti-Inflammatory Drugs) And Dementia-Related Neuropathology In A Community-Based Autopsy Cohort
Opioids may influence the development of Alzheimer’s disease (AD). Some studies have observed AD pathology in the brains of opioid…
Read on PubMed• January 2017
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Glucose Levels During Life And Neuropathologic Findings At Autopsy Among People Never Treated For Diabetes
We evaluated associations between glucose and dementia-related neuropathologic findings among people without diabetes treatment history to elucidate mechanisms of glucose’s…
Read on PubMed• December 2016
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Tuberous Sclerosis Complex: Hamartin And Tuberin Expression In Renal Cysts And Its Discordant Expression In Renal Neoplasms
Tuberous sclerosis complex (TSC) results from mutation of TSC1 or TSC2 that encode for hamartin and tuberin.
Read on PubMed• November 2016
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Epigenetic Regulation Of Klk7 Gene Expression In Pancreatic And Cervical Cancer Cells
Kallikrein-related peptidase 7 (KLK7) is a serine protease encoded within the kallikrein gene cluster located on human chromosome region 19q13.3-13.4.
Read on PubMed• November 2016