Research Publications

Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

By Johnathan O.H. Napier, Lyle J. Burdine, Coley SM, Sharma SG, Cassol CA, Kenan DJ, Eigbire-Molen O

July 2024

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue,…

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue, based on the amount of cortex. The model was developed on smartphone images of 747 kidney biopsy cores from deceased donor kidneys,…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

By Palmer MB, Royal V, Jennette JC, Smith AR, Liu Q, Ambruzs JM, Andeen NK, D'Agati VD, Fogo AB, Gaut J, Gbadegesin RA, Greenbaum LA, Hou J, Helmuth ME, Lafayette RA,…

October 2023

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD),…

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA nephropathy. We developed a conventional,…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

By Kouri AM, Caza TN, Beck LH Jr., Misurac JM, Evans MD, Phillips CL, Eadon MT, Larsen CP, Andreoli SP, Bu L, Rheault MN, Khalid M

August 2023

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected…

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected children are scarce. In recent years, several novel antigens have been implicated in the pathogenesis of PMN. However, the…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

By Bu L, Said SM, Herrera Hernandez L, Taheri Z, Spry L, Rosenthal BS, Das A, Madden B, Larsen CP, Kim Y, Sethi S, Nasr SH

August 2023

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously…

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously addressed only in case reports or small series (≤12 patients). The target antigen(s) in MN associated with anti-GBM nephritis are…

About Our Research

We’ve doubled down on our commitment to research and teaching.

Arkana is a learning, teaching, and innovating practice with one unifying passion – to actively work toward the day that our research yields breakthroughs that make our services unnecessary. Eradicating rare and common diseases is the end game of all of our efforts because patient health is foremost in our minds every day. Read about some of our latest publications below.

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Ecology Of The Aging Human Brain

By Sonnen JA, Santa Cruz K, Hemmy LS, Woltjer R, Leverenz JB, Montine KS, Jack CR, Kaye J, Lim K, Larson EB, White L, Montine TJ

Alzheimer disease, cerebral vascular brain injury, and isocortical Lewy body disease (LBD) are the major contributors to dementia in community-…

Read on PubMed

• August 2011
Novel Late-Onset Alzheimer Disease Loci Variants Associate With Brain Gene Expression

By Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, et al

Recent genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) identified 9 novel risk loci. Discovery of functional variants within…

Read on PubMed

• July 2011
Cognitive Activities During Adulthood Are More Important Than Education In Building Reserve

By Reed BR, Dowling M, Tomaszewski Farias S, Sonnen J, Strauss M, Schneider JA, Bennett DA, Mungas D

Cognitive reserve is thought to reflect life experiences. Which experiences contribute to reserve and their relative importance is not understood.…

Read on PubMed

• July 2011
Neuropathological Associates Of Multiple Cognitive Functions In Two Community-Based Cohorts Of Older Adults

By Dowling NM, Tomaszewski Farias S, Reed BR, Sonnen JA, Strauss ME, Schneider JA, Bennett DA, Mungas D

Studies of neuropathology-cognition associations are not common and have been limited by small sample sizes, long intervals between autopsy and…

Read on PubMed

• July 2011
Diagnosis Of IgG4-Related Tubulointerstitial Nephritis

By Raissian Y, Nasr SH, Larsen CP, Colvin RB, Smyrk TC, Takahashi N, Bhalodia A, Sohani AR, Zhang L, Chari S, Sethi S, Fidler ME, Cornell LD

IgG4-related systemic disease is an autoimmune disease that was first recognized in the pancreas but also affects other organs.

Read on PubMed

• June 2011
The Morphologic Spectrum And Clinical Significance Of Light Chain Proximal Tubulopathy With And Without Crystal Formation

By Larsen CP, Bell JM, Harris AA, Messias NC, Wang YH, Walker PD

The renal diseases most frequently associated with myeloma include amyloidosis, monoclonal immunoglobulin deposition disease, and cast nephropathy.

Read on PubMed

• June 2011
Cowpox Virus Induces Interleukin-10 Both In Vitro And In Vivo

By Spesock AH, Barefoot BE, Ray CA, Kenan DJ, Gunn MD, Ramsburg EA, Pickup DJ

Cowpox virus infection induces interleukin-10 (IL-10) production from mouse bone marrow-derived dendritic cells (BMDCs) or cells of the mouse macrophage…

Read on PubMed

• June 2011
Effects Of Hyperbaric Oxygen On The Expression Of Claudins After Cerebral Ischemia-Reperfusion In Rats

By Zhao H, Zhang Q, Xue Y, Chen X, Haun RS

The malfunction of tight junctions (TJs) between endothelial cells in the blood brain barrier (BBB) is the pathophysiological basis for…

• May 2011
Proteolytic Action Of Kallikrein-Related Peptidase 7 Produces Unique Active Matrix Metalloproteinase-9 Lacking The C-Terminal Hemopexin Domains

By Ramani VC, Kaushal GP, Haun RS

The gelatinases, matrix metalloproteinase (MMP)-9 and -2, are produced as latent, inactive enzymes that can be proteolytically activated by a…

Read on PubMed

• May 2011
Spontaneous Resolution Of Hiv-Associated Nephropathy In An Elite Controller

By Blankson JN, Basseth CR, Kuperman M, Fine DM

HIV-1-associated nephropathy (HIVAN) is a progressive disease characterized by collapsing focal segmental glomerulosclerosis (FSGS) and proteinuria.

Read on PubMed

• May 2011

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Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

About Our Research

All Publications

Ecology Of The Aging Human Brain

Novel Late-Onset Alzheimer Disease Loci Variants Associate With Brain Gene Expression

Cognitive Activities During Adulthood Are More Important Than Education In Building Reserve

Neuropathological Associates Of Multiple Cognitive Functions In Two Community-Based Cohorts Of Older Adults

Diagnosis Of IgG4-Related Tubulointerstitial Nephritis

The Morphologic Spectrum And Clinical Significance Of Light Chain Proximal Tubulopathy With And Without Crystal Formation

Cowpox Virus Induces Interleukin-10 Both In Vitro And In Vivo

Effects Of Hyperbaric Oxygen On The Expression Of Claudins After Cerebral Ischemia-Reperfusion In Rats

Proteolytic Action Of Kallikrein-Related Peptidase 7 Produces Unique Active Matrix Metalloproteinase-9 Lacking The C-Terminal Hemopexin Domains

Spontaneous Resolution Of Hiv-Associated Nephropathy In An Elite Controller

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Featured Publications

About Our Research

All Publications

Effects Of Hyperbaric Oxygen On The Expression Of Claudins After Cerebral Ischemia-Reperfusion In Rats

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