Featured Publications
About Our Research
We’ve doubled down on our commitment to research and teaching.
Arkana is a learning, teaching, and innovating practice with one unifying passion – to actively work toward the day that our research yields breakthroughs that make our services unnecessary. Eradicating rare and common diseases is the end game of all of our efforts because patient health is foremost in our minds every day. Read about some of our latest publications below.
All Publications
(475 Results)
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Adjustment For Selection Bias In Observational Studies With Application To The Analysis Of Autopsy Data
The interpretation of neuropathological studies of dementia and Alzheimer’s disease is complicated by potential selection mechanisms that can drive whether…
Read on PubMed• January 2009
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Nociceptive And Anxiety-Like Behavior In Reproductively Competent And Reproductively Senescent Middle-Aged Rats
Changes in levels of estradiol and progesterone that occur with the transition to reproductive senescence may influence nociception or affect.
Read on PubMed• January 2009
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Alcohol Dose-Dependently Enhances 3α-Androstanediol Formation In Frontal Cortex of Male Rats Concomitant with Aggression
Alcohol (EtOH) can enhance aggression in people and animal models. These effects are more salient in males than in females.…
Read on Betham Open• January 2009
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Increasing 3alpha,5alpha-Thp Following Inhibition Of Neurosteroid Biosynthesis In The Ventral Tegmental Area Reinstates Anti-Anxiety, Social, And Sexual Behavior Of Naturally Receptive Rats
The progesterone metabolite and neurosteroid, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), has actions in the midbrain ventral tegmental area (VTA) to modulate lordosis, but…
Read on PubMed• September 2008
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Estrogen Is Necessary For 5α-Pregnan-3α-ol-20-One (3α,5α-THP) Infusion To The Ventral Tegmental Area To Facilitate Social And Sexual, But Neither Exploratory Nor Affective Behavior Of Ovariectomized Rats
The progesterone metabolite, 5-pregnan-3-ol-20-one (3,5-THP, allopregnanolone), acts in the ventral tegmental area (VTA) to facilitate exploratory, anti-anxiety, and socio-sexual behavior…
Read on PubMed• August 2008
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Biomarkers For Cognitive Impairment And Dementia In Elderly People
The threat of a looming pandemic of dementia in elderly people highlights the compelling need for the development and validation…
Read on PubMed• August 2008
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Exploratory, Anti-Anxiety, Social, And Sexual Behaviors Of Rats In Behavioral Estrus Is Attenuated With Inhibition Of 3α,5α-Thp Formation In The Midbrain Ventral Tegmental Area
The progesterone (P4) metabolite and neurosteroid, 5-pregnan-3-ol-20-one (3,5-THP) acts in the midbrain ventral tegmental area (VTA) to modulate lordosis of…
Read on PubMed• June 2008
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Free Radical-Mediated Damage To Brain In Alzheimer’s Disease And Its Transgenic Mouse Models
Advances in our understanding of the etiologies and pathogenesis of Alzheimer’s disease (AD) highlight a role for free radical-mediated injury…
Read on PubMed• April 2008
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Estrous Cycle, Pregnancy, And Parity Enhance Performance Of Rats In Object Recognition Or Object Placement Tasks
Ovarian hormone elevations are associated with enhanced learning/memory. During behavioral estrus or pregnancy, progestins, such as progesterone (P(4)) and its…
Read on PubMed• April 2008
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Pathological Correlates Of Dementia In A Longitudinal, Population-Based Sample Of Aging
Previously published community- or population-based studies of brain aging and dementia with autopsy were restricted to a single sex, a…
Read on PubMed• October 2007
