Research Publications

Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

By Johnathan O.H. Napier, Lyle J. Burdine, Coley SM, Sharma SG, Cassol CA, Kenan DJ, Eigbire-Molen O

July 2024

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue,…

We developed a machine learning model to perform binary classification of smartphone images of kidney biopsy tissue, based on the amount of cortex. The model was developed on smartphone images of 747 kidney biopsy cores from deceased donor kidneys,…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

By Palmer MB, Royal V, Jennette JC, Smith AR, Liu Q, Ambruzs JM, Andeen NK, D'Agati VD, Fogo AB, Gaut J, Gbadegesin RA, Greenbaum LA, Hou J, Helmuth ME, Lafayette RA,…

October 2023

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD),…

Cure Glomerulonephropathy (CureGN) is an observational cohort study of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA nephropathy. We developed a conventional,…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

By Kouri AM, Caza TN, Beck LH Jr., Misurac JM, Evans MD, Phillips CL, Eadon MT, Larsen CP, Andreoli SP, Bu L, Rheault MN, Khalid M

August 2023

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected…

Primary membranous nephropathy (PMN) is uncommon in children. Therefore, data on the clinical course of affected children are scarce. In recent years, several novel antigens have been implicated in the pathogenesis of PMN. However, the…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

By Bu L, Said SM, Herrera Hernandez L, Taheri Z, Spry L, Rosenthal BS, Das A, Madden B, Larsen CP, Kim Y, Sethi S, Nasr SH

August 2023

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously…

Concurrent anti-glomerular basementmembrane (GBM) nephritis and membranous nephropathy (MN) is rare and previously addressed only in case reports or small series (≤12 patients). The target antigen(s) in MN associated with anti-GBM nephritis are…

About Our Research

We’ve doubled down on our commitment to research and teaching.

Arkana is a learning, teaching, and innovating practice with one unifying passion – to actively work toward the day that our research yields breakthroughs that make our services unnecessary. Eradicating rare and common diseases is the end game of all of our efforts because patient health is foremost in our minds every day. Read about some of our latest publications below.

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The Clinical Significance Of Receiving A Kidney Allograft From Deceased Donor With Chronic Histologic Changes

By Batal I, Serban G, Mohan S, Husain SA, Vasilescu ER, Crew RJ, Dube G, Sandoval PR, Coley SM, Santoriello D, Stokes MB, D'Agati VD, Cohen DJ, Markowitz G, Hardy MA, Ratner LE

In this report, we explored the reasons behind this guarded outcome with a special focus on the role of alloimmunity.

Read on PubMed

• September 2021
Glomerular Disease In Temporal Association To SARS-CoV-2 Vaccination: A Series of 29 Cases

By Caza TN, Cassol CA, Messias NC, Hannoudi A, Haun RS, Walker PD, May RM, Seipp RM, Betchick EJ, Amin H, Ziadie MS, Haderlie M, Eduwu-okwuwa J, Vancea I, Seek M, Elashi EB, Shenoy G, Khalillullah S, Flaxenburg JA, Brandt J, Diamond MJ, Grome A, Kim EH, Schlessinger G, Ulozas E, Weatherspoon JL, Hoerschgen ET, Gabian SL, Bae SY, Iqbal B, Chouhan KK, Karam Z, Henry JT, Larsen CP

Immune responses to vaccination are a known trigger for a new onset of glomerular disease or disease flare in susceptible…

Read on PubMed

• August 2021
Histological Evaluation Of Vaginal Cavity Remnants Excised During Neourethral Stricture Repair In Transgender Men

By Schardein JN, Li G, Zaccarini DJ, Caza T, Nikolavsky D

Objective:To determine the prevalence of patients who require vaginal cavity remnant excision and obliteration during neourethral stricture repair and to…

Read on PubMed

Schardein JN, Li G, Zaccarini DJ, Caza TN, Nikolavsky D •

• August 2021
A Multi-Center Retrospective Cohort Study Defines The Spectrum Of Kidney Pathology In Coronavirus 2019 Disease (Covid-19)

By May RM, Cassol C, Hannoudi A, Larsen CP, Lerma E, Haun RS, Braga JR, Hassen SI, Wilson J, VanBeek C, Vankalakunti M, Barnum L, Walker PD, Bourne TD, Messias NC, Ambruzs JM, Boils CL, Sharma SS, Cossey LN, Baxi PV, Palmer M, Zuckerman J, Walavalkar V, Urisman A, Gallan A, Al-Rabadi LF, Rodby R, Luyckx V, Espino G, Santhana-Krishnan S, Alper B, Lam SG, Hannoudi GN, Matthew D, Belz M, Singer G, Kunaparaju S, Price D, Chawla S, Rondla C, Abdalla MA, Britton ML, Paul S, Ranjit U, Bichu P, Williamson SR, Sharma Y, Gaspert A, Grosse P, Meyer I, Vasudev B, El Kassem M, Velez JCQ, Caza TN

Kidney failure is common in patients with Coronavirus Disease-19 (COVID-19), resulting in increased morbidity and mortality.

Read on PubMed

• August 2021
Deep-Learning-Driven Quantification Of Interstitial Fibrosis In Digitized Kidney Biopsies

By Zheng Y, Cassol CA, Jung S, Veerapaneni D, Chitalia VC, Ren KYM, Bellur SS, Boor P, Barisoni LM, Waikar SS, Betke M, Kolachalama VB

Interstitial fibrosis and tubular atrophy (IFTA) on a renal biopsy are strong indicators of disease chronicity and prognosis.

Read on PubMed

• August 2021
In Vivo Proton Magnetic Resonance Spectroscopy Detection Of Metabolite Abnormalities In Aged Tat-Transgenic Mouse Brain

By Paris JJ, Chen X, Anderson J, Qrareya AN, Mahdi F, Du F, McLaughlin JP, Kaufman MJ

Most individuals living with HIV in the USA are over 45 years old and are vulnerable to the combined effects…

Read on PubMed

• August 2021
Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy

By Caza TN, Hassen SI, Kenan DJ, Storey A, Arthur JM, Herzog C, Edmondson RD, Bourne DT, Beck LH Jr., Larsen CP

Membranous lupus nephritis (MLN) comprises 10%15% of lupus nephritis and increases morbidity and mortality of patients with SLE through complications…

Read on Kidney360

• August 2021
Thymic Stromal Lymphopoietin Induces Adipose Loss Through Sebum Hypersecretion

By Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, May RM, Robertson TF, Pai RL, Nace A, Hopkins C, Jacobsen EA, Haldar M, FitzGerald GA, Behrens EM, Minn AJ, Seale P, Cotsarelis G, Kim B, Seykora JT, Li M, Arany Z, Kambayashi T

Emerging studies indicate that the immune system can regulate systemic metabolism.

Read on PubMed

• July 2021
Red Algal Sulfated Galactan Binds And Protects Neural Cells From Hiv-1 Gp120 And Tat

By Pomin VH, Mahdi F, Jin W, Zhang F, Linhardt RJ, Paris JJ

The potential neuroprotective capacity of four different sulfated glycans:Botryocladia occidentalis-derived sulfated galactan (BoSG) (MW > 100 kDa),Lytechinus variegatus-derived sulfated fucan…

Read on PubMed

• July 2021
Neural Cell Adhesion Molecule 1 Is A Novel Autoantigen In Membranous Lupus Nephritis

By Caza TN, Hassen SI, Kuperman M, Sharma SG, Dvanajscak Z, Arthur J, Edmondson R, Storey A, Herzog C, Kenan DJ, Larsen CP

Membranous lupus nephritis is a frequent cause of nephrotic syndrome in patients with systemic lupus erythematosus.

Read on PubMed

• July 2021

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Featured Publications

Smartphone-Based Machine Learning Model for Real-Time Assessment of Medical… Smartphone-Based Machine Learning Model for…

Cure Glomerulonephropathy Pathology Classification and Core Scoring Criteria,… Cure Glomerulonephropathy Pathology Classification…

Clinical and Histopathologic Characteristics of Pediatric Patients With Primary… Clinical and Histopathologic Characteristics of…

The Characteristics of Concurrent Anti-Glomerular Basement Membrane Nephritis and… The Characteristics of Concurrent Anti-Glomerular…

About Our Research

All Publications

The Clinical Significance Of Receiving A Kidney Allograft From Deceased Donor With Chronic Histologic Changes

Glomerular Disease In Temporal Association To SARS-CoV-2 Vaccination: A Series of 29 Cases

Histological Evaluation Of Vaginal Cavity Remnants Excised During Neourethral Stricture Repair In Transgender Men

A Multi-Center Retrospective Cohort Study Defines The Spectrum Of Kidney Pathology In Coronavirus 2019 Disease (Covid-19)

Deep-Learning-Driven Quantification Of Interstitial Fibrosis In Digitized Kidney Biopsies

In Vivo Proton Magnetic Resonance Spectroscopy Detection Of Metabolite Abnormalities In Aged Tat-Transgenic Mouse Brain

Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy

Thymic Stromal Lymphopoietin Induces Adipose Loss Through Sebum Hypersecretion

Red Algal Sulfated Galactan Binds And Protects Neural Cells From Hiv-1 Gp120 And Tat

Neural Cell Adhesion Molecule 1 Is A Novel Autoantigen In Membranous Lupus Nephritis

Featured Publications

About Our Research

All Publications

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